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# Amylyx secures Bachem agreement and outlines PolyPeptide avexitide reservation
- URL: https://www.tidemetrix.com/amylyx-secures-bachem-agreement-and-outlines-polypeptide-avexitide-reservation/
- Published: 2026-09-08T14:19:00.000Z
- Updated: 2026-10-05T14:25:17.000Z
- Description: Amylyx is securing multiple sources of prospective avexitide supply, with a $30 million PolyPeptide reservation fee revealing the cost of manufacturing access.
- Author: TideMetrix Editorial
- Tags: APIs, #brief

Amylyx disclosed a signed manufacturing and supply agreement with Bachem Americas dated September 8 and a September 1 term sheet with PolyPeptide. Both concern long-term avexitide drug-substance supply for commercial use, if approved.

Bachem’s agreement requires minimum annual purchases from 2028 and partly binding forecasts. It has an initial five-year term with automatic three-year renewals, annual cost-related price adjustments, and maintenance fees and expenses.

The PolyPeptide arrangement requires a definitive manufacturing agreement still to be negotiated. Its term sheet provides for a $30 million upfront capacity-reservation fee; the filing does not confirm payment. Minimum purchases from 2028, partly binding forecasts and annually adjustable volume-based pricing are contemplated subject to execution of that agreement.

Both suppliers are non-exclusive. Amylyx may procure from other manufacturers, but discloses neither quantities nor allocations between suppliers.

The filing identifies drug substance, not finished-dose manufacturing. Sites, production routes and clinical-supply roles are undisclosed. The reservation establishes prospective supply access, not a physical capacity addition or confirmation that two qualified commercial sources are operating.

### Sources

Amylyx — September 8 SEC Form 8-K, Item 1.01